diff --git a/default.yaml b/default.yaml
index 44b170e4..e934ef26 100644
--- a/default.yaml
+++ b/default.yaml
@@ -418,8 +418,13 @@ accounts:
             #     username: "admin"
             #     password: "hunter2"
             #     implicit-tls: false # TLS from the first byte, typically on port 465
-            blacklist-regexes:
-            #    - ".*@mailinator.com"
+            # addresses that are not accepted for registration:
+            address-blacklist:
+            #    - "*@mailinator.com"
+            address-blacklist-syntax: "glob" # change to "regex" for regular expressions
+            # file of newline-delimited address blacklist entries in the above syntax;
+            # supersedes address-blacklist if set:
+            # address-blacklist-file: "/path/to/address-blacklist-file"
             timeout: 60s
             # email-based password reset:
             password-reset:
diff --git a/irc/email/email.go b/irc/email/email.go
index 4b0834b7..07c7bc52 100644
--- a/irc/email/email.go
+++ b/irc/email/email.go
@@ -4,10 +4,13 @@
 package email
 
 import (
+	"bufio"
 	"bytes"
 	"errors"
 	"fmt"
+	"io"
 	"net"
+	"os"
 	"regexp"
 	"strings"
 	"time"
@@ -23,6 +26,38 @@ var (
 	ErrNoMXRecord         = errors.New("Couldn't resolve MX record")
 )
 
+type BlacklistSyntax uint
+
+const (
+	BlacklistSyntaxGlob BlacklistSyntax = iota
+	BlacklistSyntaxRegexp
+)
+
+func blacklistSyntaxFromString(status string) (BlacklistSyntax, error) {
+	switch strings.ToLower(status) {
+	case "glob", "":
+		return BlacklistSyntaxGlob, nil
+	case "re", "regex", "regexp":
+		return BlacklistSyntaxRegexp, nil
+	default:
+		return BlacklistSyntaxRegexp, fmt.Errorf("Unknown blacklist syntax type `%s`", status)
+	}
+}
+
+func (bs *BlacklistSyntax) UnmarshalYAML(unmarshal func(interface{}) error) error {
+	var orig string
+	var err error
+	if err = unmarshal(&orig); err != nil {
+		return err
+	}
+	if result, err := blacklistSyntaxFromString(orig); err == nil {
+		*bs = result
+		return nil
+	} else {
+		return err
+	}
+}
+
 type MTAConfig struct {
 	Server      string
 	Port        int
@@ -35,24 +70,64 @@ type MailtoConfig struct {
 	// legacy config format assumed the use of an MTA/smarthost,
 	// so server, port, etc. appear directly at top level
 	// XXX: see https://github.com/go-yaml/yaml/issues/63
-	MTAConfig            `yaml:",inline"`
-	Enabled              bool
-	Sender               string
-	HeloDomain           string `yaml:"helo-domain"`
-	RequireTLS           bool   `yaml:"require-tls"`
-	VerifyMessageSubject string `yaml:"verify-message-subject"`
-	DKIM                 DKIMConfig
-	MTAReal              MTAConfig `yaml:"mta"`
-	BlacklistRegexes     []string  `yaml:"blacklist-regexes"`
-	blacklistRegexes     []*regexp.Regexp
-	Timeout              time.Duration
-	PasswordReset        struct {
+	MTAConfig              `yaml:",inline"`
+	Enabled                bool
+	Sender                 string
+	HeloDomain             string `yaml:"helo-domain"`
+	RequireTLS             bool   `yaml:"require-tls"`
+	VerifyMessageSubject   string `yaml:"verify-message-subject"`
+	DKIM                   DKIMConfig
+	MTAReal                MTAConfig       `yaml:"mta"`
+	AddressBlacklist       []string        `yaml:"address-blacklist"`
+	AddressBlacklistSyntax BlacklistSyntax `yaml:"address-blacklist-syntax"`
+	AddressBlacklistFile   string          `yaml:"address-blacklist-file"`
+	blacklistRegexes       []*regexp.Regexp
+	Timeout                time.Duration
+	PasswordReset          struct {
 		Enabled  bool
 		Cooldown custime.Duration
 		Timeout  custime.Duration
 	} `yaml:"password-reset"`
 }
 
+func (config *MailtoConfig) compileBlacklistEntry(source string) (re *regexp.Regexp, err error) {
+	if config.AddressBlacklistSyntax == BlacklistSyntaxGlob {
+		return utils.CompileGlob(source, false)
+	} else {
+		return regexp.Compile(fmt.Sprintf("^%s$", source))
+	}
+}
+
+func (config *MailtoConfig) processBlacklistFile(filename string) (result []*regexp.Regexp, err error) {
+	f, err := os.Open(filename)
+	if err != nil {
+		return
+	}
+	defer f.Close()
+	reader := bufio.NewReader(f)
+	lineNo := 0
+	for {
+		line, err := reader.ReadString('\n')
+		lineNo++
+		line = strings.TrimSpace(line)
+		if line != "" && line[0] != '#' {
+			if compiled, compileErr := config.compileBlacklistEntry(line); compileErr == nil {
+				result = append(result, compiled)
+			} else {
+				return result, fmt.Errorf("Failed to compile line %d of blacklist-regex-file `%s`: %w", lineNo, line, compileErr)
+			}
+		}
+		switch err {
+		case io.EOF:
+			return result, nil
+		case nil:
+			continue
+		default:
+			return result, err
+		}
+	}
+}
+
 func (config *MailtoConfig) Postprocess(heloDomain string) (err error) {
 	if config.Sender == "" {
 		return errors.New("Invalid mailto sender address")
@@ -68,12 +143,20 @@ func (config *MailtoConfig) Postprocess(heloDomain string) (err error) {
 		config.HeloDomain = heloDomain
 	}
 
-	for _, reg := range config.BlacklistRegexes {
-		compiled, err := regexp.Compile(fmt.Sprintf("^%s$", reg))
+	if config.AddressBlacklistFile != "" {
+		config.blacklistRegexes, err = config.processBlacklistFile(config.AddressBlacklistFile)
 		if err != nil {
 			return err
 		}
-		config.blacklistRegexes = append(config.blacklistRegexes, compiled)
+	} else if len(config.AddressBlacklist) != 0 {
+		config.blacklistRegexes = make([]*regexp.Regexp, 0, len(config.AddressBlacklist))
+		for _, reg := range config.AddressBlacklist {
+			compiled, err := config.compileBlacklistEntry(reg)
+			if err != nil {
+				return err
+			}
+			config.blacklistRegexes = append(config.blacklistRegexes, compiled)
+		}
 	}
 
 	if config.MTAConfig.Server != "" {
@@ -118,8 +201,9 @@ func ComposeMail(config MailtoConfig, recipient, subject string) (message bytes.
 }
 
 func SendMail(config MailtoConfig, recipient string, msg []byte) (err error) {
+	recipientLower := strings.ToLower(recipient)
 	for _, reg := range config.blacklistRegexes {
-		if reg.MatchString(recipient) {
+		if reg.MatchString(recipientLower) {
 			return ErrBlacklistedAddress
 		}
 	}
diff --git a/traditional.yaml b/traditional.yaml
index 811a1e7d..7ffbdd84 100644
--- a/traditional.yaml
+++ b/traditional.yaml
@@ -391,8 +391,13 @@ accounts:
             #     username: "admin"
             #     password: "hunter2"
             #     implicit-tls: false # TLS from the first byte, typically on port 465
-            blacklist-regexes:
-            #    - ".*@mailinator.com"
+            # addresses that are not accepted for registration:
+            address-blacklist:
+            #    - "*@mailinator.com"
+            address-blacklist-syntax: "glob" # change to "regex" for regular expressions
+            # file of newline-delimited address blacklist entries in the above syntax;
+            # supersedes address-blacklist if set:
+            # address-blacklist-file: "/path/to/address-blacklist-file"
             timeout: 60s
             # email-based password reset:
             password-reset: